Understanding the role of innate immune cells in regulating gut-associated lymphoid tissues at steady-state and in disease

肠道是形成外部环境和身体之间的保护屏障的最大表面积。它是抵御入侵病原体的第一道防线。肠道的免疫系统对于保护这一组织至关重要-任何破坏都会导致肠道的严重和进行性炎症性疾病，如慢性炎症性肠病。我们的工作将确定保护肠道的关键机制，为靶向肠道免疫治疗打开大门。

The intestine is the largest surface area forming a protective barrier between the external environment and the body. It represents the first line of defence against invading pathogens. The immune system of the intestine is critical to protect this tissue -any breakdown leads to profound and progressive inflammatory disease of the gut such as chronic inflammatory bowel disease. Our work will determine the critical the mechanisms that protect the gut opening the door to targeted intestinal immunotherapeutics.