Understanding the role of host Arih2 in defence against viral infection and disease pathogenesis

一组被称为E3连接酶的蛋白质调节免疫的许多方面。Arih 2是一种新的E3连接酶，它限制免疫细胞的激活，使免疫系统处于静止状态。Arih2的功能及其在慢性压倒性感染免疫中的作用是本研究的重点。从这些研究中获得的见解对我们理解在感染期间如何促进免疫反应或在自身免疫中如何停止免疫反应具有重要意义。

A set of proteins, called E3 ligases, modulate many aspects of immunity. Arih 2 is a novel E3 ligase that limits immune cell activation to maintain the immune system in a quiescent state. The details of how Arih2 functions and its role in immunity to chronic overwhelming infection are the focus of this study. The insights gained from these studies have important implications for our understanding of how immune responses can be promoted during infection or halted in autoimmunity.