Unique and shared functions of KAT6A and KAT6B

遗传物质和相关蛋白质（称为染色质）被包装在细胞核中的方式调节着基因的活性。在癌细胞中，染色质结构是高度异常的。我们建议研究两种蛋白的联合功能，这两种蛋白在异常活跃时调节染色质结构并导致白血病。我们正在开发针对这些蛋白质的新药。这个项目将告诉我们如何最好地利用这些药物来设计新的癌症疗法。

The way in which the genetic material and associated proteins, termed chromatin, are packaged in the nucleus regulates gene activity. In cancer cells, the chromatin structure is highly abnormal. We propose to investigate the combined function of two proteins, which regulate chromatin structure and cause leukaemia when abnormally active. We are developing new drugs targeting these proteins. This project will inform how best to use these drugs in designing new therapies for cancer.