Using a national level multi-registry analysis to determine whether prescribed anti-platelet therapies post-stroke can modify the risk of cognitive decline or dementia

中风幸存者有患痴呆症的风险。中风后的血脑屏障损伤可能使血液中的药物进入大脑，这些药物可能对脑细胞有毒。氯吡格雷（Clopidogrel）是一种常用于中风后的药物，它会阻断大脑修复所必需的受体。中风后，氯吡格雷可能进入大脑，损害修复过程，增加痴呆的风险。我们将使用瑞典国家健康登记数据，将氯吡格雷的使用与卒中后痴呆的风险联系起来。

Stroke survivors are at risk of dementia. Blood brain barrier damage after stroke may allow drugs in the bloodstream, which can be toxic to brain cells, to enter the brain. Clopidogrel, a drug commonly used after stroke, blocks a receptor essential for brain repair. After stroke, clopidogrel may access the brain and compromise repair processes, increasing the risk of dementia. We will link use of clopidogrel to the risk of dementia after stroke, using national Swedish health registry data.