Using reward-based biomarkers to improve the early detection of bipolar disorder in individuals seeking treatment for depression

双相情感障碍经常被误诊为单相抑郁症，这可能会造成灾难性的临床后果。新出现的证据表明，双相情感障碍患者在处理奖赏的大脑区域中表现出特殊的功能障碍。这项研究将使用尖端的神经科学方法来研究这两种障碍的奖励处理，目的是识别有助于区分双相和单相抑郁的生物标记物。

Bipolar disorder is often misdiagnosed as unipolar major depression, which can have disastrous clinical consequences. Emerging evidence indicates that individuals with bipolar disorder show particular dysfunctions within brain regions involved in processing reward. This research will use cutting-edge neuroscience methodologies to investigate reward processing in these two disorders, with the objective of identifying biological markers that help distinguish bipolar from unipolar depression.