Vascular and neurogenic determinants of hypertension in chronic kidney disease

你的年龄和你的动脉一样大，而肾病患者的动脉衰老得很快。他们也有过度活跃的交感神经，目前还不清楚是血管还是神经导致了高血压，给这些患者的心脏和其他器官带来了压力。我们将使用动物模型来确定高血压治疗是否降低血管僵硬或神经活动升高。我们的研究结果将有助于更好地治疗肾衰竭。

You are as old as your arteries, and people with kidney disease have arteries that age fast. They also have overactive sympathetic nerves, and it is not clear if the blood vessels or nerves are responsible for the high blood pressure that puts strain on the heart and other organs of these patients. We will use an animal model to determine if therapy for hypertension reduces the stiffness of blood vessels or elevated nerve activity. Our results will enable better treatments for kidney failure.