Viral Determinants of HIV-1 Transcriptional Latency in the Central Nervous System

目前用于治疗HIV-1感染的抗HIV药物无法从体内消除病毒，因此无法治愈HIV-1感染。这些药物不能提供治愈的主要原因是因为它们不能到达隐藏在特定类型的细胞中的病毒，这种病毒被称为“蓄水池”。这项研究将确定艾滋病毒-1如何在这些水库中避难，这将是旨在治愈艾滋病毒-1感染的战略的关键信息。

The anti-HIV drugs that are currently used to treat HIV-1 infection cannot eliminate the virus from the body, and therefore, cannot cure HIV-1 infection. The major reason why the drugs cannot provide a cure is because they cannot reach virus that hides in particular cells types referred to as "reservoirs". This study will determine how HIV-1 can take sanctuary in these reservoirs, which will be critical information for strategies that aim to cure HIV-1 infection.