Virtuous cycles: a novel cyclic peptide approach to develop neuroprotective and cardioprotective drugs

每年有11万澳大利亚人中风或心脏病发作，其中2万人因此死亡。中风和心脏病发作是由于流向受影响器官的血液减少而造成的缺血性损伤。血栓溶解药物可以用来恢复血液流动，但它们不能解决缺血性损伤造成的潜在组织损害。我们的目标是开发一种药物，分别在中风和心脏病发作后保护大脑和心脏。这种药物将拯救生命，提高幸存者的生活质量。

Each year, 110,000 Australian have a stroke or heart attack, and 20,000 die as a result. Stroke and heart attack are ischemic injuries caused by reduced blood flow to the affected organ. Clot-busting drugs can be used to restore blood flow but they do not address the underlying tissue damage caused by the ischemic insult. We aim to develop a drug that protects the brain and heart after stroke and heart attack, respectively. This drug will save lives and improve quality-of-life for survivors.