Studying 24-hour rhythms of light exposure, alignment with rest-activity cycle, and cardiometabolic health in a nationally representative sample

在全国代表性样本中研究 24 小时光照节律、与休息活动周期的一致性以及心脏代谢健康

• 批准号: 10516569
• 负责人: Mariana Gross Figueiro
• 金额: $ 13.7万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-20 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10516569
• 关键词: Activity Cycles; Adult; Adverse effects; Behavior; Behavioral; Biological Markers; Blood Pressure; Body Composition; Cardiometabolic Disease; Cardiovascular Diseases; Characteristics; Circadian Rhythms; Circadian desynchrony; Clinical; Communities; Data; Data Analyses; Development; Diabetes Mellitus; Disadvantaged; Disease; Elements; Environmental Exposure; Exercise; Exposure to; General Population; Health; Hour; Human; Impairment; Investigation; Lead; Light; Light Exercise; Link; Lipids; Low income; Measurement; Measures; Metabolic Diseases; Methods; National Health and Nutrition Examination Survey; Obesity; Occupational; Outcome; Participant; Patient Self-Report; Pattern; Periodicity; Phase; Physiological; Pilot Projects; Play; Population; Process; Public Health; Publishing; Reporting; Rest; Risk Factors; Role; Sampling; Schedule; Signal Transduction; Sleep; Stimulus; Subgroup; System; Testing; Therapeutic Intervention; Time; Underrepresented Populations; Variant; Wrist; actigraphy; cardiometabolic risk; cardiometabolism; circadian; design; disease disparity; disorder risk; ethnic minority; glycemic control; health disparity; improved; insight; modifiable risk; molecular clock; novel; older men; preventive intervention; racial and ethnic; sleep health; socioeconomics; study characteristics; suprachiasmatic nucleus; therapy development

PROJECT SUMMARY Circadian rhythms, generated by endogenous molecular clocks and entrained by the light-dark cycle, play a central role in orchestrating many physiological and behavioral processes related to cardiometabolic health. A growing body of evidence has linked light exposure at different times of the day and cardiometabolic outcomes, suggesting that characteristics of 24-hour light-dark cycle may be unique predictors of disease risk. However, there is a lack of investigation focusing on comprehensively assessing 24-hour light exposure, and in particular, its alignment with diurnal behavioral, to understand its health implications in human populations. A well- established hallmark of a healthy circadian timing system is the synchronization and proper alignment of multiple elements, such as between the environmental stimuli (e.g., light-dark cycle) and diurnal behaviors (e.g., activity- rest cycle). Our pilot study in older men applied phasor analysis to assess the alighnment between actigraphy- measured 24-hour light-dark and activity-rest cycles, and we found that impaired alignment between the two was associated with diabetes. These findings suggest that poor synchronization between the timing of light exposure and activity patterns may be a unique predictor of cardiometabolic risk, a novel hypothesis that needs to be tested in broader populations. We propose to test this hypothesis by conducting secondary data analysis in the National Health and Nutrition Examination Survey (NHANES, 2011-2014), which has detailed data on 24-hour light and activity patterns and rich information on cardiometabolic health. Moreover, the diverse and nationally representative sample will allow us to determine how 24-hour patterns of light exposure, its interrelationship with activity-rest cycles, and their associations with cardiometabolic outcomes may vary among subgroups with different demographic, socioeconomic, and occupational characteristics. Aim 1 Study characteristics of 24- hour light exposure and its alignment with rest and activity patterns in relation to cardiometabolic health in adult participants in NHANES. In this aim we will apply parametric and nonparametric methods to characterize multiple aspects of light-dark cycles and phasor analysis to characterize the alignment between light-dark and activity-rest cycles to study their associations with cardiometabolic outcomes. Aim 2 Study light exposure, alignment with rest and activity, and their associations with cardiometabolic health in adult populations with different demographic, socioeconomic and occupational attributes. In this aim we will examine multiple population attributes as determinants of 24-hour light-dark cycles and its alignment with activity- rest cycles, and as moderators of the association between light exposure and cardiometabolic health. Light exposure is a potentially modifiable risk factor for cardiometabolic diseases, and our study will help better understand the contribution of light exposure to cardiometabolic health and disease disparities, and provide evidence for developing preventive and therapeutic interventions aimed at manipulating light exposure and activity-rest patterns to improve circadian function and cardiometabolic health.

项目概要 昼夜节律由内源性分子钟产生并受到明暗周期的影响，发挥着 在协调与心脏代谢健康相关的许多生理和行为过程中发挥着核心作用。一个 越来越多的证据表明一天中不同时间的光照与心脏代谢结果有关， 这表明 24 小时光暗周期的特征可能是疾病风险的独特预测因子。然而， 缺乏针对24小时光照综合评估的调查，特别是： 它与昼夜行为的一致性，以了解其对人类健康的影响。一个井- 健康昼夜节律系统的既定标志是多个生物钟的同步和正确对齐 元素，例如环境刺激（例如，光暗循环）和昼夜行为（例如，活动）之间 休息周期）。我们对老年男性的初步研究应用相量分析来评估体动记录之间的一致性 测量了 24 小时的光-暗和活动-休息周期，我们发现两者之间的一致性受损 与糖尿病有关。这些发现表明，光照时间之间的同步性较差 活动模式可能是心脏代谢风险的独特预测因素，这是一个需要进一步研究的新假设 在更广泛的人群中进行了测试。我们建议通过进行二次数据分析来检验这一假设 全国健康与营养调查（NHANES，2011-2014），其中有24小时的详细数据 光线和活动模式以及有关心脏代谢健康的丰富信息。此外，多元化和全国性 代表性样本将使我们能够确定 24 小时光照模式及其与 活动-休息周期及其与心脏代谢结果的关联可能因亚组而异 不同的人口、社会经济和职业特征。目标 1 研究 24- 的特征 小时光照及其与心脏代谢健康相关的休息和活动模式的一致性 NHANES 的成人参与者。为此，我们将应用参数和非参数方法 表征光暗循环和相量分析的多个方面，以表征之间的对齐 光-暗和活动-休息周期来研究它们与心脏代谢结果的关系。目标 2 研究灯 暴露、休息和活动的配合及其与成人心脏代谢健康的关系 具有不同人口、社会经济和职业属性的人口。为了这个目标我们将 检查多种人口属性作为 24 小时明暗周期的决定因素及其与活动的一致性 休息周期，并作为光照与心脏代谢健康之间关联的调节因素。光 暴露是心脏代谢疾病的一个潜在可改变的危险因素，我们的研究将有助于更好地 了解光照对心脏代谢健康和疾病差异的影响，并提供 制定旨在控制光照和治疗的预防和治疗干预措施的证据 活动-休息模式可改善昼夜节律功能和心脏代谢健康。