Sedentary Behavior and Cardiovascular Health in Young Women

年轻女性的久坐行为与心血管健康

基本信息

批准号：
10623317
负责人：
Bethany Barone Gibbs
金额：
$ 60.65万
依托单位：
WEST VIRGINIA UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-05-20 至 2027-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10623317
关键词：
Acceleration Accelerometer Activity Cycles Acute Address Adverse event Age Ancillary Study Autonomic Dysfunction Behavior Behavior Therapy Behavior assessment Behavioral Blood Pressure Body mass index Calibration Cardiac health Cardiovascular Diseases Cardiovascular system Cholesterol Clinical Data Development Disease Outcome Epidemiology Exposure to Female Glucose Guidelines High Risk Woman Indiana Intervention Laboratories Leisures Life Style Link Lipids Longitudinal cohort Measurement Measures Modality Monitor Mothers Nature Nulliparity Outcome Study Patient Self-Report Pattern Persons Physical activity Physiologic pulse Posture Pregnancy Pregnancy Outcome Recommendation Recording of previous events Reporting Research Resources Risk Risk Factors Role Self Correction Sex Differences Statistical Methods Sum Testing Thigh structure Time United States National Institutes of Health Woman adverse pregnancy outcome arterial stiffness behavior measurement blood pressure elevation cardiovascular disorder prevention cardiovascular disorder risk cardiovascular health cardiovascular risk factor clinical development cohort critical period design fasting glucose heart rate variability high risk high risk population improved innovation light intensity men middle age modifiable risk novel novel strategies post pregnancy prospective response sedentary lifestyle sex standard measure therapy development vigorous intensity young adult young woman

项目摘要

ABSTRACT Women have more rapid cardiovascular disease (CVD) risk development compared to men during young adulthood; yet, little research has studied factors that could curtail CVD risk development during this critical period for young women. The Nulliparous Pregnancy Outcomes Study Monitoring Mothers-to-Be Heart Health Study (nuMoM2b HHS) is a unique, multi-center, longitudinal cohort, originating during the first pregnancy, that is now studying associations between adverse pregnancy outcomes (APO) and modifiable CVD risk in women. This ancillary application to nuMoM2b HHS aims to test our hypotheses that sedentary behavior (SED) is a key, modifiable risk factor for CVD risk development in young women, including those with APO. SED is low-intensity behavior in a seated, reclining, or lying posture and has recently been identified as a CVD risk factor that is distinct from insufficient moderate-to-vigorous intensity activity (MVPA). Acute prolonged sitting results in marked, adverse responses such as increased blood pressure (BP), glucose, and lipids. Yet, major research gaps preclude the development and testing of specific SED-reduction interventions, especially for young women. Most studies measure SED poorly (e.g., by self-report) and do not statistically consider that SED is part of an all-day activity pattern (or composition). Further, mechanisms of how SED leads to CVD are unclear, further limiting intervention development. Last, almost no studies focus on young women. Our preliminary data suggest that SED is strongly associated with APOs and reduced cardiovascular health (e.g., BP) in young women post-pregnancy. Further, our laboratory has recently demonstrated novel associations between SED and mechanistic CVD measures, including greater arterial stiffness (higher pulse wave velocity [PWV]) and worse autonomic function (lower heart rate variability [HRV]). Collectively, SED is a novel, understudied risk factor for reduced cardiovascular health that our data suggest is highly relevant for young women. We have a unique, efficient, and time-sensitive opportunity to address these gaps by adding gold standard SED assessment via activPAL thigh-mounted accelerometer to the upcoming HHS2 exam. In this contemporary and diverse female cohort (n=4,050, age=36±6 years), we aim to quantify cross-sectional and longitudinal associations of SED with the clinical components of idea cardiovascular health (BP, BMI, total cholesterol, fasting glucose) by using state-of-the-art statistical methods that consider the compositional nature of SED and 24-hr activity and can correct existing, longitudinal self-reported SED via regression calibration. Also, we add HRV and PWV in Pittsburgh and Indiana (n=950) to efficiently study associations between SED and subclinical, mechanistic CVD outcomes in young women. Aim 3 will study interrelationships of SED, APO history, and ideal cardiovascular health to identify novel risk reductions strategies in this high-risk group with limited treatment options. This research will provide critical data to rigorously link SED, CVD risk, and contributing mechanisms and will inform age- and sex-specific SED interventions to test in young women, including those with APO.

抽象的与年轻人相比，女性患心血管疾病（CVD）风险的发展更快成年然而，很少的研究因素可以减少CVD的风险发展。年轻女性时期。无效的怀孕结果研究监测准母亲的心脏健康研究（NUMOM2B HHS）是一个独特的，多中心的，纵向队列，起源于第一次怀孕，现在正在研究女性不良怀孕结果（APO）和可修改的CVD风险之间的关联。 NUMOM2B HHS的辅助应用旨在检验我们的假设，即久坐行为（SED）是关键，年轻女性（包括APO）的CVD风险发展的可修改风险因素。 SED是座位，斜倚或撒谎的姿势中的低强度行为，最近被确定为CVD 风险因素不同于现代到毒的强度活动不足（MVPA）。急性长时间坐着导致明显的不良反应，例如血压升高（BP），葡萄糖和脂质。但是，少校研究差距排除了特定SED减少干预措施的开发和测试，尤其是针对年轻女性。大多数研究的测量很差（例如，通过自我报告），并且在统计上不认为SED 是全天活动模式（或组成）的一部分。此外，SED如何导致CVD的机制尚不清楚，进一步限制干预开发。最后，几乎没有研究专注于年轻女性。我们的初步数据表明SED与年轻女性的APO密切相关，并降低心血管健康（例如BP）怀孕后。此外，我们的实验室最近证明了SED和机械性CVD测量值，包括更大的动脉刚度（较高的脉搏波速度[PWV]）和更糟自主功能（较低的心率变异性[HRV]）。总体而言，SED是一个新颖的，理解的风险因素我们的数据表明的心血管健康降低与年轻女性高度相关。我们有一个独特，高效和时间敏感的机会，可以通过添加黄金标准来解决这些差距通过ActivPal大腿安装的加速度计进行SED评估，以进行即将进行的HHS2考试。在这个当代和Divers雌性队列（n = 4,050，年龄= 36±6岁），我们旨在量化横截面和纵向 SED与想法心血管健康的临床成分（BP，BMI，总胆固醇，禁食）的关联葡萄糖）通过使用最先进的统计方法来考虑SED和24小时的组成性质活动并可以通过回归校准纠正现有的纵向自我报告的SED。另外，我们添加了HRV和匹兹堡和印第安纳州的PWV（n = 950）有效研究SED和亚临床之间的关联年轻女性的机械CVD结果。 AIM 3将研究SED，APO历史和理想的相互关系心血管健康以识别这个高风险群体的新型风险降低策略，并有限选项。这项研究将为严格连接SED，CVD风险和贡献机制提供关键数据并将为年龄和性别特定的SED干预措施提供信息，以对年轻女性（包括APO患者）进行测试。