Viscerosensory neuroimmune interactions

免疫系统在疼痛中的作用正在从最近的发现中浮现出来，并且可能是新型疼痛治疗的关键。大多数人会因为食物或传染病而经历短暂的肠道感染，但不会有长期后果。许多人在多年后仍会出现症状——这可能是免疫疼痛的最好例子。我们的项目研究免疫细胞如何与感觉神经交流，以及这些交流在肠道感染或炎症后如何从两个角度改变。

The role of the immune system in pain is emerging from recent discoveries, and may hold the key to novel pain treatments. Most people experience brief gut infections from food or contagion without long-term consequences. Many others suffer symptoms for years afterwards - probably the best example of immune-based pain. Our project investigates how immune cells communicate with sensory nerves, and how these communications change from both angles after gut infection or inflammation.