GABA(B) Receptor Modulation of Gastrointestinal Function in Health and Disease by Alpha-Conotoxins

α-芋螺毒素对健康和疾病中胃肠功能的 GABA(B) 受体调节

• 批准号: nhmrc : 1049928
• 负责人: A/Pr Stuart Brierley
• 金额: $ 45.95万
• 依托单位: University of Wollongong
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/gabab-receptor-modulation-alpha-conotoxins/112125
• 关键词: GABA; Receptor; Modulation; Gastrointestinal; Function

Chronic visceral pain is a common and debilitating condition arising from numerous diseases that affect our internal organs. There is a desperate need for more information about the mechanisms responsible for signalling chronic visceral pain to provide therapies and potentially find a cure for it. Our research focuses on ?-conotoxins (small peptides from marine cone snail venom) as novel potential therapeutic agents for the treatment of chronic visceral pain.

慢性内脏疼痛是一种常见的和衰弱的条件所产生的许多疾病，影响我们的内部器官。我们迫切需要更多关于慢性内脏疼痛信号机制的信息，以提供治疗方法并可能找到治愈方法。我们的研究重点是？芋螺毒素（来自海洋芋螺毒液的小肽）作为治疗慢性内脏痛的新的潜在治疗剂。