Interaction of TRP channels and inflammatory mediators: A critical role in visceral pain

TRP 通道和炎症介质的相互作用：在内脏疼痛中发挥关键作用

• 批准号: nhmrc : 497803
• 负责人: A/Pr Stuart Brierley
• 金额: $ 20.59万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/interaction-trp-channels-visceral-pain/115499
• 关键词: Interaction; TRP; channels; inflammatory; mediators

Transient receptor potential, or TRP channels, are involved in generating many of the sensations we feel, such as touch and pain. The function of these channels can be altered by substances released by the body during inflammation. Some TRP channels have specialized roles in signalling pain from the colon which can be enhanced during colonic inflammation. Understanding how TRP channels and inflammatory mediators function and interact is essential if we are to find treatments for colonic pain.

瞬时受体电位，或TRP通道，参与产生我们感觉到的许多感觉，如触摸和疼痛。这些通道的功能可以被炎症期间身体释放的物质改变。一些TRP通道在从结肠发出疼痛信号中具有特殊作用，其可以在结肠炎症期间增强。了解TRP通道和炎症介质的功能和相互作用是必不可少的，如果我们要找到治疗结肠疼痛。