Is overactive bladder a 'Bladder itch'? Identification of itch specific pathways within the bladder

膀胱过度活动症是“膀胱痒”吗？

• 批准号: nhmrc : GNT1140297
• 负责人: A/Pr Stuart Brierley
• 金额: $ 72.06万
• 依托单位: Flinders University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/overactive-bladder-bladder-pathways-bladder/1348294
• 关键词: overactive; bladder; Bladder; itch; Identification

Overactive bladder is a leading cause of nocturia, urgency and incontinence. These symptoms arise from sensory nerve fibres in the bladder. We have identified key irritant mechanisms, including the bile acid receptor TGR5 and Mrgpr family, thought to only exist in the skin, also innervate the bladder. We hypothesis that the clinical entity overactive bladder, is triggered by pathological activation of bladder afferents by such irritants and that overactive bladder is essentially a bladder itch.

膀胱过度活动是夜尿、尿急和尿失禁的主要原因。这些症状是由膀胱中的感觉神经纤维引起的。我们已经确定了关键的刺激机制，包括胆汁酸受体TGR5和Mrgpr家族，被认为只存在于皮肤中，也支配膀胱。我们假设临床实体膀胱过度活跃，是由这些刺激物引起的膀胱传入神经的病理激活引发的，而膀胱过度活跃本质上是膀胱瘙痒。