In vivo responses to pathogen-derived mediators of acute inflammation

脓毒症在世界范围内造成大量死亡。目前尚不清楚为什么有些患者能够耐受感染并完全康复，而其他患有同等感染的患者则非常容易患上严重疾病并死于败血症。心力衰竭是脓毒症常见的基础疾病。这项研究将重点关注感染如何导致心脏性猝死。这将对严重感染和婴儿猝死综合征患者的护理产生影响。

Sepsis causes large numbers of deaths worldwide. It is not known why some patients tolerate an infection and fully recover, while other patients with an equivalent infection are highly vulnerable to severe illness and death from sepsis. Heart failure is a common underlying condition in sepsis. This research will focus on how an infection can cause sudden cardiac death. It will have implications for care of patients with severe infection and also sudden infant death syndrome.