Label free high sensitivity detection of bacteria by phages using functionalized optical microcavities

这项提议解决了加拿大目前面临和今后几十年将面临的挑战。正如最近在国际舞台上看到的那样，由细菌传播的新发和再次出现的传染病可能会威胁到人们的健康。为了解决这些问题，加拿大将需要先进的生物医学技术，以便及早发现人类和动物的传染病。病原菌的检测在医疗诊断、医院感染、食品安全、生物战等各个领域都非常重要。为了制定预防计划，或在细菌污染事件中制定有效的干预计划，有必要进行显著、特异和快速的检测。目前的检测需要几天甚至几周的时间才能确认患者存在病原体和其他传染病的诊断。以手持设备的形式开发负担得起的诊断技术，例如护理点测试(POTC)设备，将提供更及时和更准确的测试结果。POTC非常有趣，因为它可以在患者护理现场进行，例如在急诊室、战场、门诊部、疗养院、患者家中或医院床边，结果可能导致患者护理的变化。

This proposal addresses challenges that Canada is facing presently and will face for the next few decades. As seen recently on the international scene, emerging and re-emerging infectious diseases propagated by bacteria might threaten populations' health. To address these issues, Canada will need advanced biomedical technologies for early detection of infectious diseases in humans and animals. Detection of pathogenic bacteria is very important in various sectors like medical diagnosis, nosocomial infections, food safety, and biological war. In order to establish a prevention plan, or an effective intervention plan in the event of bacterial contamination, it is necessary to carry out a significant, specific and fast detection. Current tests require days and even weeks to confirm a diagnosis of the presence of a pathogen and other infectious diseases in a patient. The development of affordable diagnostic technologies, such as Point-of-Care Testing (POTC) devices, in the form of hand-held devices will provide for more timely and accurate test results. POTC is extremely interesting since it can be performed at the site of the patient care, such as in emergency rooms, battlefields, outpatient clinics, nursing homes, patients' homes or hospital bedside, with the result leading to possible change in the care of the patient.