Modular confocal laser microscope system

需要资金紧急更换共聚焦荧光显微镜系统，该系统具有确定极薄薄膜内结构和反应动力学的核心仪器能力。Krull的研究计划专注于设计化学选择性表面，用于开发生物传感器和通过测量荧光强度运行的生物分析。这些技术使用直接固定在表面上的选择性探针，以便在生物识别事件中结合目标可以提供局部可测量的分析信号。当与微流控相结合时，这种技术可以提供出色的选择性，并可以将探针材料的完全反应时间从几个小时减少到几分钟。

Funds are requested for the urgent replacement of a confocal fluorescence microscope system that affords a core instrumental capability for determination of the structure and reaction dynamics within very thin films. Krull's research program focuses on the design of chemically-selective surfaces for development of biosensors and bioassays that operate by measuring fluorescence intensity. These technologies use selective probes that are immobilized directly to a surface so that binding of target in a bio-recognition event can provide for a localized measurable analytical signal. When combined with microfluidic flow control, such technology can offer outstanding selectivity, and can reduce the time for complete reaction of the probe material from several hours to several minutes.