Structure and function of acyl carrier protein

我的研究试图发现酰基载体蛋白（ACP），一个关键的中心蛋白在细菌脂肪酸合成，可以识别和区分它的多个蛋白质的合作伙伴。这些合作伙伴包括超过三十打酶参与合成膜脂，毒素（如。内毒素）和细菌生长和致病的其它必需组分。ACP必须折叠以封闭附着的脂肪酸，因为它携带它们通过细胞的水环境，但必须随后展开以在与ACP依赖性酶相互作用时释放它们。 我们认为ACP是一种特殊的柔性和动态蛋白质，具有对酶结合和触发酰基链的展开和释放重要的特定氨基酸。

My research is trying to discover how acyl carrier protein (ACP), a key central protein in bacterial fatty acid synthesis, can recognize and discriminate among its multiple protein partners. These partners include over three dozen enzymes involved in synthesis of membrane lipids, toxins (eg. endotoxin), and other essential components of bacterial growth and pathogenesis. ACP must fold to enclose attached fatty acids as it carries them through the watery environment of the cell, but must then unfold to release them upon interaction with ACP-dependent enzymes. We believe that ACP is a special flexible and dynamic protein, with specific amino acids important for enzyme binding and triggering the unfolding and release of the acyl chain.