Lead optimization of new antibacterials/antimalarials that target ACP synthase

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This project focuses on producing new antibiotic drugs that are "broad-spectrum" to treat all types of drug-resistant bacterial infections as well as, potentially, tuberculosis and malaria. Drug resistance is a growing problem that has made current antibiotics much less effective than before. This is of special concern in resistant strains of Staph. aureus (the "superbug" MRSA); Gram-negative infections caused by E. coli; so-called "XDR" tuberculosis caused by strains of Mycobacterium tuberculosis; and malaria, the causative agent of which is Pl. falciparum. All of these diverse diseases can be targeted by the same drug, provided the mechanism of action is present in all of them. This proposal uses novel compounds that kill MRSA, developed in previous work, as a starting point for making such broad-spectrum antibiotics. Our compounds target ACP