Synthesis and Characterization of Transition-Metal Sulfide Fluorides, and Main-Group Fluorides and Oxide Fluorides

氟是最活泼的元素。它的反应性使得制备结构简单的小分子成为可能，如果没有氟元素的存在，这些分子将是不稳定的。对分子结构的基础研究有助于化学家检验理论的有效性;这些理论适用于从新材料到药物的许多实际问题。拟议的研究将涉及制备具有硫和氟围绕中心金属原子的新型化合物。这些所谓的硫化物氟化物是研究其反应化学的起点。由于在生物系统中发现了硫络合物，如铁氧化还原蛋白，因此将研究氟对这些硫络合物性质的影响。硫化物氟化物的潜在用途是作为石油工业中的催化剂。这些硫化物氟化物与其他金属阳离子的组合预计会导致更大的聚集体。如果有可能增加它们的尺寸，这些化合物可以用作材料。将研究硫化物氟化物作为氟化剂的利用，并可能导致它们在制药工业中用于制备氟化药物，例如作为抗乳腺癌药物的5-氟尿嘧啶和抗抑郁药氟西汀和帕罗西汀，这些药物已被证明具有显着的效力。这些无机硫化物氟化物将通过固体状态下的NMR光谱法等手段进行表征。这种表征技术对含氟化合物的研究尚处于起步阶段。该提案旨在将固态NMR光谱扩展到各种无机氟化合物。

Fluorine is the most reactive element. Its reactivity makes possible to prepare small, structurally simple molecules that would be unstable without the presence of the element fluorine. Basic studies of molecular structures help chemists check the validity of theories; theories that are applied to a host of practical problems, from new materials to pharmaceuticals. The proposed research will involve the preparation of novel compounds that have sulfur and fluorine surrounding a central metal atom. These so-called sulfide fluorides are the starting point for the study of their reaction chemistry. Since sulfur complexes are found in biological systems, such as ferredoxins, the influence of fluorine on the nature of those sulfur complexes will be investigated. The potential use of sulfide fluorides is as catalysts in the petroleum industry. The combination of these sulfide fluorides with other metal cations is expected to result in larger aggregations. If it is possible to increase their size, these compounds could be used as materials. The utilization of sulfide fluorides as fluorination agents will be studied and may result in their use in the pharmaceutical industry to prepare fluorinated drugs, such as 5-fluorouracil as a drug against breast cancer and the antidepressants fluoxetine and paroxetine, which have been proven to possess remarkable potencies. These inorganic sulfide fluorides will be characterized, among other means, by NMR spectroscopy in the solid state. This characterization technique is still in its infancies for fluorine-containing compounds. The proposal pursues the extension of solid-state NMR spectroscopy to a large variety of inorganic fluorine compounds.