Development and evaluation of novel bone anchors and "smart" adaptive implants for the treatment of the bone deficient skeleton

由于骨折或骨组织丢失导致骨骼生物力学完整性的丧失通常会导致过早残疾，并使患者的生活质量下降。骨骼疾病，如骨质疏松相关骨折、溶骨性骨质流失和其他与创伤、骨肿瘤和手术切除相关的骨缺陷，给卫生保健系统带来了巨大的经济负担。尽管在植入物设计、增强方法和再生医学方法方面进行了大量的研究，但骨缺损的手术治疗仍然具有挑战性，临床结果不令人满意。

Loss of the biomechanical integrity of the skeleton due to fracture or loss of bone tissue often leads to premature disability and leaves the patient with a reduced quality of life. The economic burden on the health care system of skeletal conditions such as osteoporosis-related fractures, osteolytic bone loss and other bone defects related to trauma, bone tumors and surgical resections is enormous. Despite considerable research efforts in implant design, augmentation methods and regenerative medicine approaches, the surgical treatment of the bone deficient skeleton remains challenging with unsatisfactionary clinical outcomes.