Distillers dried grains with solubles (DDGS) as a potential source of immunomodulatory and growth promoting activity for poultry

据估计，在不久的将来，加拿大的乙醇厂每年将生产130-140万吨玉米和小麦蒸馏干粮(DDGS)，用于动物和家禽饲料。为了从这些副产品中获得最大的价值，必须向家禽业展示它们作为饲料成分的天然优势。DDGS是啤酒酵母(Saccharmyces Cerevisiae)发酵的副产物，含有大量有益于肠道发育和健康的成分(即1，3-和1，6-葡聚糖、核苷酸、甘露聚糖寡糖或多糖)，并有效地刺激免疫系统。本研究的目的是研究玉米和小麦DDGS与酿造和烘焙行业的酵母衍生产品对肉鸡胃肠道发育、免疫系统功能和生长性能的影响。外源酶可用于修饰和提高引入鸟类消化系统的活性碳水化合物成分的利用率。这些补充剂的潜在协同效应和酶技术的使用将被调查。本研究的里程碑是：1.研究酵母产品中不同的碳水化合物和核苷酸衍生物对天然免疫和获得性免疫的影响；2.利用建立的产气荚膜梭菌坏死性肠炎鸡模型，测定日粮中DDGS的免疫调节和促生长作用。这项研究将有助于我们更好地了解DDGS联合产品的营养价值，并将促进玉米和小麦DDGS这两种加拿大重要饲料资源在家禽日粮中的有效利用。

It is estimated, that in the near future the ethanol plants in Canada will generate 1.3-1.4 million tonnes of corn and wheat distillers dried grains with solubles (DDGS) destined for animal and poultry feeding per year. In order to derive maximum value from these co-products, their natural advantage as feed ingredients must be presented to the poultry industry. DDGS are co-products of brewer's yeast (Saccharomyces cerevisiae) fermentation which contain significant quantities of components (i.e., ß1,3- and ß1,6-glucans, nucleotides, mannan oligo- or polysaccharides) beneficial for gut development and health, and effective in immune system stimulation. The objective of the proposed research is to investigate the effect of corn- and wheat-based DDGS vs. yeast-derived products of brewing and bakery industries on gastrointestinal tract development, immune system function and growth performance of broiler chickens. Exogenous enzyme can be used to modify and to increase availability of active carbohydrate components upon introduction to the bird's digestive system. Potential synergistic effect of these supplements and the use of enzyme technology will be investigated. The milestones of this research are: 1. To investigate the effect of different carbohydrates and nucleotides derivatives from yeast products on innate and acquired immunity, and 2. To determine the immunomodulating and growth promoting effect of dietary DDGS using the chicken model developed for inducing necrotic enteritis caused by Clostridium perfringens. This research will contribute to our better understanding of the nutritive value of DDGS co-products and will promote the use of corn and wheat DDGS, important Canadian feed resources, effectively in poultry rations.