Development of a botanical anxiolytic for the animal health market

这项研究将产生一种新的商业天然健康产品（NHP），用于治疗动物焦虑症，并最终进入人类健康市场。抗焦虑产品是一种热带藤蔓植物，以前在我们与哥斯达黎加植物学家合作的发现研究计划中被确定。它已被证明是安全和高度有效的动物模型的焦虑使用大鼠，小鼠和仔猪和技术现已授权给加拿大公司的发展。将这一基础研究转化为动物健康市场的天然健康产品，需要仔细选择种质，身份和质量保证，配方，野生收获的可持续方法，并过渡到种植。这些问题在拟定的工作中得到解决，并将产生一种统一的、可重现的产品，该产品将与我们在圭尔夫大学进行犬临床试验的团队提供的产品相当。鉴于最近兽医和动物主人对狗和马的NHP治疗的兴趣，该产品将及时进入大型动物保健市场。该项目将通过在国际市场上销售一种创新的新产品、雇用熟练的农村劳动力，为加拿大和哥斯达黎加提供社会经济利益。该项目强调了正在消失的热带植物物种的价值，并满足了动物健康方面尚未满足的需求。

The proposed research will lead to a new commercial natural health product (NHP)derived to treat anxiety in animals and eventually the human health market. The antianxiety product is a tropical vine which was previously identified in our discovery research program in collaboration with Costa Rican botanists. It has been shown to be safe and highly effective in animal models of anxiety using rats, mice and piglets and the technology has now been licenced to a Canadain company for development. Translation of this fundamental research to produce a natural health product for the animal health market market requires careful choice of germ plasm, identity and quality assurance, formualtion, sustainable methods for wild harvest with a transition to cultivation. These issues are addressed in the proposed work and will lead to a uniform, reproducible product that will be comparable to that provided by our team for clincial trials with dogs at University of Guelph. Given the recent interest by veterinarians and animal owners in NHP treatments for dogs and horses, the product will make a timely effort into the large animal health care market. The project will provide socio-economic benefits to Canada and Costa Rica through sales of an innovative new product on the international market, employment of both a skilled and a rural workforce. The project highlights the value of disappearing tropical plant species and meets an unmet need in animal health.