Effect of two prebiotics on gut microflora in healthy and Salmonella challenged broilers

消化道中细菌的多样性集合，统称为肠道微生物区系，在肉鸡的营养、健康和疾病中起着重要作用。益生元是不易消化的食物成分，通过选择性地刺激肠道中存在的细菌种类的生长而使宿主受益。 本提案的目的是了解两种益生元，甘露寡糖（MOS）和低聚木糖（XOS），如何改变鸡胃肠道中的微生物生态，从而提高生产性能和健康。该提案将目前AviMicroNet研究的范围扩大到抗生素的新型替代品。它将阐明益生元如何影响肠道菌群在生理和病理（沙门氏菌挑战模型）阶段。肠道沙门氏菌血清型沙门氏菌和肠道沙门氏菌血清型鼠伤寒沙门氏菌，经常从健康、患病或死亡的禽类中分离出来，是引起人类疾病的血清型，最常与禽肉和禽蛋相关（CDC，2008）。家禽肉在加工过程中可能会被带菌者禽类的肠道内容物意外污染。食用受沙门氏菌污染和烹饪不当的鸡肉和鸡蛋与人类疾病有关。通过开发有效的益生元，有可能减少人类沙门氏菌病病例。

The diverse collection of bacteria in the digestive tract, collectively referred to as the gut microflora, plays an important role in the nutrition, health and disease of broiler chickens. Prebiotics are non-digestible food ingredients that benefit the host by selectively stimulating the growth of bacterial species present in the gut. The aim of this proposal is to understand how two prebiotics, mannan-oligosaccharide (MOS) and xylo-oligosaccharide (XOS), modify the microbial ecology in the chicken gastro-intestinal tract, consequently improving production performance and health. This proposal expands the scope of current AviMicroNet research towards novel alternatives to antibiotics. It will shed light on how prebiotics affects gut microflora during physiological and pathological (Salmonella challenge model) stages. Salmonella enterica serovar enteritidis and Salmonella enterica serovar typhimurium, frequently isolated from healthy, diseased or dead birds, are the human illness causing serovars most commonly associated with poultry meat and eggs (CDC, 2008). Poultry meat could be contaminated accidentally from intestinal contents of carrier birds during processing. The consumption of Salmonella contaminated and improperly cooked chicken meat and eggs has been associated with human illnesses. By development of effective prebiotics, it is possible to reduce salmonellosis cases in human.