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The role of post-translational modifications of MRE11 in mediating the DNA damage response.

The role of post-translational modifications of MRE11 in mediating the DNA damage response.
MRE11 翻译后修饰在介导 DNA 损伤反应中的作用。
批准号：
237790
负责人：
Richard Stphane
金额：
$63.62万
依托单位：
Lady Davis Institute for Medical Research (Mtl)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2011
资助国家：
加拿大
项目状态：
已结题
起止时间：
2011-09-01 至 2016-09-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=237790&lang=en
关键词：
Arginine Methylation Dna Damage Signalling Gar Motif Genetics Mre11 Sumoylation

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中文摘要
翻译
DNA损伤的检测和修复对细胞的存活至关重要。DNA修复缺陷会导致DNA易位、缺失和突变，染色体断裂会导致基因组不稳定和癌症。几种人类遗传性疾病与
英文摘要
The detection and repair of DNA damage are vital for cell viability. DNA repair defects lead to DNA translocations, deletions and mutations, chromosome breakage leading to genomic instability and cancer. Several human genetic disorders are associated with
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