Triple Quadrupole Gas Chromatography - Tandem Mass Spectrometry (GCMS/MS) Instrument with Electron Ionization and Chemical Ionization

我们正在申请资金，以购买一种能够对化合物进行定性和定量分析的仪器。该仪器是一台与三重四极杆质谱仪(MS)耦合的气相色谱仪。质谱仪有两个电离源，i)标准电子电离源，用于通过质谱指纹识别未知化合物并确定存在多少物质；ii)较软的化学电离源，用于确定分子质量，也用于确定存在多少物质。三重四极质谱计具有在MS/MS模式下工作的能力，大大提高了信噪比和专属性，使人们即使在非常复杂的混合物中也能确定给定物质的含量。该仪器将用于支持药物化学合成，包括癌症检测的探针、抗菌肽的表征、乳腺癌和肺癌等疾病的生物标志物的测定，以及其他非常复杂的混合物的分析。

We are applying for funding to purchase an instrument that is capable of both qualitative and quantitative analysis of compounds. The instrument is a gas chromatograph coupled to a triple quadrupole mass spectrometer (MS). The mass spectrometer has two ionization sources, i) a standard electron ionization source used to both identify unknown compounds through mass spectral fingerprinting and to determine how much material is present and ii) a softer chemical ionization source used to determine molecular mass and also used in the determination of how much material is present. The triple quadrupole mass spectrometer has the capability to operate in MS/MS mode which provides greatly improved signal-to-noise and specificity allowing one to determine "how much" of a given material is present even in very complex mixtures. This instrument will be used to support medicinal chemistry synthesis including probes for cancer detection, the characterization of anti-bacterial peptides, the determination of biomarkers of diseases such as breast and lung cancers, and the analysis of other very complex mixtures.