Synthesis and Characterization of Transition-Metal Sulfide Fluorides, and Main-Group Fluorides and Oxide Fluorides

氟是最活泼的元素。它的反应性使制备结构简单的小分子成为可能，如果没有氟元素的存在，这些分子就会不稳定。分子结构的基础研究帮助化学家检验理论的正确性；应用于从新材料到药品等一系列实际问题的理论。拟议的研究将包括制备具有硫和氟围绕中心金属原子的新型化合物。这些所谓的硫化氟化物是研究它们的反应化学的起点。由于硫配合物存在于生物系统中，例如铁氧化还原素，因此将研究氟对这些硫配合物性质的影响。硫化物的潜在用途是在石油工业中作为催化剂。这些硫化物与其他金属阳离子的结合预计会产生更大的聚集。如果有可能增加它们的尺寸，这些化合物可以用作材料。将研究利用硫化物氟化物作为氟化剂，并可能将其用于制药业，以制备含氟药物，例如用于治疗乳腺癌的5-氟尿嘧啶，以及已被证明具有显著效力的抗抑郁药氟西汀和帕罗西汀。这些无机硫化物将被表征，除其他手段外，在固体状态下的核磁共振波谱。这种表征含氟化合物的技术仍处于起步阶段。该提案力求将固态核磁共振光谱扩展到各种无机氟化合物。

Fluorine is the most reactive element. Its reactivity makes possible to prepare small, structurally simple molecules that would be unstable without the presence of the element fluorine. Basic studies of molecular structures help chemists check the validity of theories; theories that are applied to a host of practical problems, from new materials to pharmaceuticals. The proposed research will involve the preparation of novel compounds that have sulfur and fluorine surrounding a central metal atom. These so-called sulfide fluorides are the starting point for the study of their reaction chemistry. Since sulfur complexes are found in biological systems, such as ferredoxins, the influence of fluorine on the nature of those sulfur complexes will be investigated. The potential use of sulfide fluorides is as catalysts in the petroleum industry. The combination of these sulfide fluorides with other metal cations is expected to result in larger aggregations. If it is possible to increase their size, these compounds could be used as materials. The utilization of sulfide fluorides as fluorination agents will be studied and may result in their use in the pharmaceutical industry to prepare fluorinated drugs, such as 5-fluorouracil as a drug against breast cancer and the antidepressants fluoxetine and paroxetine, which have been proven to possess remarkable potencies. These inorganic sulfide fluorides will be characterized, among other means, by NMR spectroscopy in the solid state. This characterization technique is still in its infancies for fluorine-containing compounds. The proposal pursues the extension of solid-state NMR spectroscopy to a large variety of inorganic fluorine compounds.