Novel antimircrobial and biofilm resistant coatings for urological and blood storage devices

这项研究解决了医院获得性感染中的严重挑战：预防与泌尿外科设备相关的细菌感染和输血用血液产品中的细菌生长。导尿管是北美医院最常用的医疗器械之一，导尿管相关感染在医院获得性感染中占很大比例。除了死亡率增加外，这些并发症还增加了数百万额外的医疗费用。目前，抗生素是我们试图处理这些感染的唯一方法，但由于导管表面生物膜固有的多重耐药性，抗生素效果不佳。输注受细菌污染的血液产品是另一个长期存在的严重并发症。在北美，每年大约有1500万个单位的包装红细胞和450万个单位的血小板被输注。与储存有关的细菌污染发生率高达1

This research addresses serious challenge in hospital acquired infections: the prevention of bacterial infections associated with urological devices and bacterial growth in blood products for transfusion. Urinary catheters is one of most frequently used medical device in hospitals in North America and catheter associated infections account for a major share of hospital acquired infectious. In addition to increased mortality, these complications add millions of extra health care costs. Currently, antibiotics are our only method of attempting to deal with these infections, but do not work well due to intrinsic multidrug resistance of biofilms on catheter surface. The transfusion of bacterial contaminated blood products is another longstanding serious complication. In North America, approximately 15 million units of packed red blood cells and 4.5 million units of platelets are transfused every year. The incidence of bacterial contamination associated with the storage is as high as 1