Platelet friendly storage bags to improve storage quality, shelf-life and prevent biofilm growth

这项研究解决了与输血相关的严重挑战： 储存血小板和防止细菌生长。血小板输注用于治疗 患有例如癌症和失血过多的患者（事故受害者）。在北 在美国，每年大约输注450万单位的血小板。目前 血小板储存在塑料容器中， 室温多年来，血小板储存方面的创新很少。质量 储存血小板的减少是由于目前的常规方法引起的表面损伤， 储物袋输注受细菌污染的血小板是另一个长期存在的严重问题。 并发症与血小板储存相关的细菌污染发生率为 高达每1500个单位中1个，并且代表了巨大的成本，因为每个血小板单位都要测试 污染，以避免患者的败血症反应。从而提高了储存的质量 血小板，保质期和开发方法，以防止细菌生长将显着 有效性，减少浪费，提高输液效率。我们的项目寻求新的 血小板储存设备基于UBC在新型一步通用上的最新突破 抑制血小板活化分子的薄膜包衣和抑制剂。拟议 该装置将改善储存血小板的质量并通过提供 与目前的储存袋相比，这种环境具有高度的细胞相容性。我们 预计这将大大延长血小板的储存寿命相比，目前 5天重要的是，这种新设备可以与新批准的 病原体灭活技术提高血小板质量。当前的优势 方法将是实质性的，因为它避免了浪费，增加了安全性，并具有显著的成本 为我们的卫生系统省钱。

This research addresses serious challenges associated with blood transfusion: quality of stored platelets and the prevention of bacterial growth. Platelet transfusion is used for treating patients suffering e.g. from cancer and excessive blood loss (accident victims). In North America, approximately 4.5 million units of platelets are transfused every year. Currently platelets are stored in plastic containers which are originally not designed to store platelets at room temperature. There is very little innovation in platelet storage over the years. The quality of stored platelets decreases due to the surface induced damage by the current conventional storage bags. Transfusion of bacterial contaminated platelets is another longstanding serious complication. The incidence of bacterial contamination associated with platelet storage is as high as 1 per every 1500 units and represents a huge cost as every platelet unit is tested for contamination to avoid septic reactions in patients. Thus improving the quality of stored platelets, shelf-life and develop methods to prevent bacterial growth will significantly availability, reduce the wastage and increase transfusion efficiency. Our project seeks novel platelet storage devices based on latest breakthroughs at UBC on novel one-step universal antibiofilm coating and inhibitors that scavenge platelet activating molecules. The proposed device will improve the quality of stored platelets and increase the shelf-life by providing an environment that is highly cell compatible in comparison to the current storage bags. We anticipate that this will extend the storage life of platelets significantly compared to the current 5 days. Importantly this new device can be used in conjunction with the newly approved pathogen inactivation technologies by improve the platelet quality. The benefits over current methods will be substantial as it avoid wastage and increase safety and have significant cost savings to our health system.