Platelet friendly storage bags to improve storage quality, shelf-life and prevent biofilm growth

血小板友好型储存袋可提高储存质量、延长保质期并防止生物膜生长

• 批准号: 549667-2020
• 负责人: Kizhakkedathu, Jayachandran
• 金额: $ 17.16万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Collaborative Health Research Projects
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=699483
• 关键词: Platelet; friendly; storage; bags; improve

This research addresses serious challenges associated with blood transfusion: quality of stored platelets and the prevention of bacterial growth. Platelet transfusion is used for treating patients suffering e.g. from cancer and excessive blood loss (accident victims). In North America, approximately 4.5 million units of platelets are transfused every year. Currently platelets are stored in plastic containers which are originally not designed to store platelets at room temperature. There is very little innovation in platelet storage over the years. The quality of stored platelets decreases due to the surface induced damage by the current conventional storage bags. Transfusion of bacterial contaminated platelets is another longstanding serious complication. The incidence of bacterial contamination associated with platelet storage is as high as 1 per every 1500 units and represents a huge cost as every platelet unit is tested for contamination to avoid septic reactions in patients. Thus improving the quality of stored platelets, shelf-life and develop methods to prevent bacterial growth will significantly availability, reduce the wastage and increase transfusion efficiency. Our project seeks novel platelet storage devices based on latest breakthroughs at UBC on novel one-step universal antibiofilm coating and inhibitors that scavenge platelet activating molecules. The proposed device will improve the quality of stored platelets and increase the shelf-life by providing an environment that is highly cell compatible in comparison to the current storage bags. We anticipate that this will extend the storage life of platelets significantly compared to the current 5 days. Importantly this new device can be used in conjunction with the newly approved pathogen inactivation technologies by improve the platelet quality. The benefits over current methods will be substantial as it avoid wastage and increase safety and have significant cost savings to our health system.

这项研究解决了与输血相关的严重挑战：输血质量 储存的血小板和防止细菌生长。血小板输注用于治疗 患有癌症和失血过多的患者(事故受害者)。在北方 在美国，每年大约有450万个单位的血小板被输注。目前 血小板储存在塑料容器中，而塑料容器最初不是用来储存血小板的 常温的。多年来，在血小板储存方面几乎没有什么创新。质量 由于目前常规方法引起的表面损伤，储存的血小板的数量减少 储物袋。输注受细菌污染的血小板是另一个长期严重的问题 很复杂。与储存血小板有关的细菌污染发生率为 每1500个单位高达1个，这意味着巨大的成本，因为每个血小板单位都要进行检测 污染，以避免患者的败血症反应。从而提高了存储的质量 血小板、保质期和制定防止细菌生长的方法将显著 使用方便，减少浪费，提高输液效率。我们的项目寻求新奇 基于UBC在新型一步通用上的最新突破的血小板存储设备 清除血小板激活分子的抗生物膜涂层和抑制剂。建议数 设备将改善储存的血小板的质量并通过提供 与目前的储存袋相比，这种环境具有高度的电池兼容性。我们 预计与目前相比，这将显著延长血小板的储存寿命 5天。重要的是，这种新设备可以与新批准的 病原体灭活技术通过提高血小板质量来实现。比现在的好处 方法将是实质性的，因为它避免了浪费，增加了安全性，而且成本很高 为我们的医疗系统节省开支。