Platelet friendly storage bags to improve storage quality, shelf-life and prevent biofilm growth

这项研究解决了与输血相关的严重挑战：储存血小板的质量和防止细菌生长。血小板输注用于治疗患有例如癌症和失血过多的患者（事故受害者）。在北美，每年约输注450万个单位的血小板。目前，血小板储存在塑料容器中，这些容器最初不是设计用于在室温下储存血小板的。多年来，血小板储存方面的创新很少。目前常用的血小板储存袋由于其表面损伤，导致血小板储存质量下降。输注被细菌污染的血小板是另一个长期存在的严重并发症。与血小板储存相关的细菌污染的发生率高达每1500单位中有1个，并且代表了巨大的成本，因为每个血小板单位都要进行污染测试以避免患者的败血症反应。因此，提高储存血小板的质量、保存期限和防止细菌生长的方法将显著提高血小板的利用率，减少浪费，提高输血效率。我们的项目寻求基于UBC在新型一步通用薄膜涂层和抑制血小板活化分子的抑制剂方面的最新突破的新型血小板储存装置。与目前的储存袋相比，所提出的装置将提高储存血小板的质量，并通过提供高度细胞相容的环境来延长保质期。我们预计，这将大大延长血小板的储存寿命相比，目前的5天。重要的是，这种新设备可以与新批准的病原体灭活技术结合使用，通过提高血小板质量。与目前的方法相比，这种方法的好处将是巨大的，因为它避免了浪费，提高了安全性，并为我们的卫生系统节省了大量成本。

This research addresses serious challenges associated with blood transfusion: quality ofstored platelets and the prevention of bacterial growth. Platelet transfusion is used for treatingpatients suffering e.g. from cancer and excessive blood loss (accident victims). In NorthAmerica, approximately 4.5 million units of platelets are transfused every year. Currentlyplatelets are stored in plastic containers which are originally not designed to store platelets atroom temperature. There is very little innovation in platelet storage over the years. The qualityof stored platelets decreases due to the surface induced damage by the current conventionalstorage bags. Transfusion of bacterial contaminated platelets is another longstanding seriouscomplication. The incidence of bacterial contamination associated with platelet storage is ashigh as 1 per every 1500 units and represents a huge cost as every platelet unit is tested forcontamination to avoid septic reactions in patients. Thus improving the quality of storedplatelets, shelf-life and develop methods to prevent bacterial growth will significantlyavailability, reduce the wastage and increase transfusion efficiency. Our project seeks novelplatelet storage devices based on latest breakthroughs at UBC on novel one-step universalantibiofilm coating and inhibitors that scavenge platelet activating molecules. The proposeddevice will improve the quality of stored platelets and increase the shelf-life by providing anenvironment that is highly cell compatible in comparison to the current storage bags. Weanticipate that this will extend the storage life of platelets significantly compared to the current5 days. Importantly this new device can be used in conjunction with the newly approvedpathogen inactivation technologies by improve the platelet quality. The benefits over currentmethods will be substantial as it avoid wastage and increase safety and have significant costsavings to our health system.