Platelet friendly storage bags to improve storage quality, shelf-life and prevent biofilm growth

这项研究解决了与输血相关的严重挑战：储存血小板的质量和细菌生长的预防。血小板输注用于治疗癌症和失血过多的病人（事故受害者）。在北美，每年大约有450万单位的血小板输注。目前，血小板被储存在塑料容器中，而塑料容器最初并不是用来在室温下储存血小板的。多年来，在血小板储存方面几乎没有什么创新。目前的传统储存袋由于表面引起的损伤而降低了储存血小板的质量。输注被细菌污染的血小板是另一个长期存在的严重并发症。与血小板储存相关的细菌污染发生率高达每1500个单位中有1个，这意味着巨大的成本，因为每个血小板单位都要进行污染检测，以避免患者发生脓毒性反应。因此，提高储存血小板的质量、保质期和开发防止细菌生长的方法将显著提高可用性，减少浪费，提高输血效率。我们的项目寻求基于UBC在新型一步通用抗生素膜涂层和清除血小板激活分子抑制剂方面的最新突破的新型血小板存储设备。与目前的储存袋相比，拟议的设备将提供一个高度细胞兼容的环境，从而提高储存血小板的质量并延长保质期。我们预计这将大大延长血小板的储存寿命，而不是目前的5天。重要的是，这种新设备可以通过提高血小板质量与新批准的病原体灭活技术结合使用。与目前的方法相比，这种方法的好处将是巨大的，因为它避免了浪费，提高了安全性，并为我们的卫生系统节省了大量成本。

This research addresses serious challenges associated with blood transfusion: quality ofstored platelets and the prevention of bacterial growth. Platelet transfusion is used for treatingpatients suffering e.g. from cancer and excessive blood loss (accident victims). In NorthAmerica, approximately 4.5 million units of platelets are transfused every year. Currentlyplatelets are stored in plastic containers which are originally not designed to store platelets atroom temperature. There is very little innovation in platelet storage over the years. The qualityof stored platelets decreases due to the surface induced damage by the current conventionalstorage bags. Transfusion of bacterial contaminated platelets is another longstanding seriouscomplication. The incidence of bacterial contamination associated with platelet storage is ashigh as 1 per every 1500 units and represents a huge cost as every platelet unit is tested forcontamination to avoid septic reactions in patients. Thus improving the quality of storedplatelets, shelf-life and develop methods to prevent bacterial growth will significantlyavailability, reduce the wastage and increase transfusion efficiency. Our project seeks novelplatelet storage devices based on latest breakthroughs at UBC on novel one-step universalantibiofilm coating and inhibitors that scavenge platelet activating molecules. The proposeddevice will improve the quality of stored platelets and increase the shelf-life by providing anenvironment that is highly cell compatible in comparison to the current storage bags. Weanticipate that this will extend the storage life of platelets significantly compared to the current5 days. Importantly this new device can be used in conjunction with the newly approvedpathogen inactivation technologies by improve the platelet quality. The benefits over currentmethods will be substantial as it avoid wastage and increase safety and have significant costsavings to our health system.