Universal Antibiofilm Coating Solutions for Ureteral Stents

适用于输尿管支架的通用抗菌膜涂层解决方案

• 批准号: 493634-2016
• 负责人: Kizhakkedathu, Jayachandran
• 金额: $ 19.89万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Collaborative Health Research Projects
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=621866
• 关键词: Universal; Antibiofilm; Coating; Solutions; Ureteral

This research addresses serious challenge in hospital acquired infections: the prevention of bacterial infections associatedwith ureteral stents. Ureteral stents are commonly used by a urology surgeon in the treatment of kidney stone and ureterproblem associated with cancer, infection etc. Urinary devices account for >80% of hospital acquired infections which aredifficult to treat. In addition to increased mortality, these complications add millions of extra health care costs. Currently,antibiotics are our only method of attempting to deal with these infections, but do not work well due to intrinsic multidrugresistance of biofilms on stent surface. The project is based on the latest breakthroughs at UBC on the development of anovel universal coating method to prevent bacterial attachment and protein binding, and the discovery of novel short broadspectrum anti-bioflim peptides (ABPs). This project will discover and invent novel technologies which can prevent infectionand other stent related complications by developing a novel coating on the ureteral stent surface which will prevent bacterialgrowth, deposition of biological molecules on the stent surface from urine and with excellent biocompatibility. We anticipatethat the technologies developed will help >3 million Canadians who needs urological intervention. The project will establish astrong collaboration among natural science, and medicine, and provide unique HQP training opportunities. The novel antiinfectioncoatings will also provide a general method for preventing infections associated with other medical devices.

本研究旨在解决医院获得性感染的严重挑战：预防输尿管支架相关的细菌感染。输尿管支架是泌尿外科医生治疗肾结石和输尿管癌、感染等疾病的常用方法，泌尿系统感染占医院获得性感染的80%以上，这些并发症除了增加死亡率外，还增加了数百万的医疗费用。目前，抗生素是我们试图处理这些感染的唯一方法，但由于支架表面生物膜的内在多药耐药性，抗生素效果不佳。该项目基于UBC在开发新型通用涂层方法以防止细菌附着和蛋白质结合以及发现新型短广谱抗生物膜肽（ABP）方面的最新突破。本项目将通过在输尿管支架表面开发一种新型涂层来发现和发明预防感染和其他支架相关并发症的新技术，该涂层将防止细菌生长，防止尿液中生物分子在支架表面沉积，并具有良好的生物相容性。我们预计，开发的技术将帮助> 300万需要泌尿外科干预的加拿大人。该项目将在自然科学和医学之间建立强有力的合作，并提供独特的HQP培训机会。新型抗感染涂层也将为预防与其他医疗器械相关的感染提供一种通用方法。