A general utility centrifugation apparatus for cellular and macromolecular studies

离心法是一种物理过程，它利用旋转产生离心力，使稠密的颗粒或液体在复杂的混合物中沉淀。细胞和分子生物学家以及生物化学家使用该仪器(离心机)分离和分离生物物质，特别是细胞、细胞器和大分子。我们小组研究不同类型细胞的生物学功能。这一知识很重要，因为异常的细胞功能和调节是包括癌症、感染性疾病和自身免疫性疾病在内的几种恶性肿瘤的基础。为了更好地了解细胞功能，我们需要培养细菌、酵母和来自哺乳动物器官的各种细胞类型。这些细胞被少量或大量地收获，用于各种研究。目前的拨款申请汇集了一组由NSERC资助的团队，对他们来说，每天都迫切需要进行离心机分离。因此，完成每项研究计划所需的设备是不可或缺的。

Centrifugation is a physical process that consists in the use of spining to create a centrifugal force that sedimentates dense particles or liquids in complex mixtures. Cell and molecular biologists as well as biochemists use the instrument (centrifuge) to separate and fractionate biological material, particularly cells, organelles and macromolecules. Our group studies the biological functions of various cell types. This knowledge is important since abnormal cell function and regulation is the basis of several malignancies including cancer, infectious and autoimmune diseases. To better understand cell function, we need to culture bacteria, yeast and various cell types originating from mammalian organs. These cells are harvested in small or large quantities to be used for various investigations. The current grant application brings together a group of NSERC-funded teams for whom, the centrifugation is critically required on a daily basis. Therefore the requested equipment is indispensable for the accomplishment of each research program.