Unraveling the function and the mechanism of action of the deubiquitinase MYSM1

揭示去泛素酶 MYSM1 的功能和作用机制

• 批准号: RGPIN-2015-05381
• 负责人: Affar, ElBachir
• 金额: $ 2.48万
• 依托单位: Université de Montréal
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=590394
• 关键词: Unraveling; function; mechanism; action; deubiquitinase

A biochemical reaction called ubiquitination plays a central role in regulating a wide variety of processes that are important for virtually all kingdoms of life. The covalent attachment of ubiquitin to proteins involves a distinct class of proteins called ubiquitin ligases, which represent the most abundant enzymes of the ubiquitin system. Although most often associated with degradation and disposal of unwanted proteins, ubiquitination is also involved in regulatory events in degradation-independent manner.

一种被称为泛素化的生化反应在调节几乎所有生命王国都重要的各种过程中起着核心作用。泛素与蛋白质的共价连接涉及一类称为泛素连接酶的独特蛋白质，其代表了泛素系统中最丰富的酶。尽管泛素化通常与不需要的蛋白质的降解和处置有关，但它也以不依赖降解的方式参与调控事件。