Capillary differential scanning calorimeter

我们正在申请资助毛细管差示扫描量热计（DSC）；该仪器是测量所有主要生物分子（包括蛋白质、核酸、脂类和碳水化合物以及较小的配体，如金属离子）与结构转变和结合相互作用相关的能量变化的强大工具。因此，DSC是一种独特而宝贵的工具，用于分析控制大量生物分子系统结构和功能的能量学。在自然界、生物技术和医学中，对这种能量学的理解对于操纵和控制这些系统的行为至关重要。虽然在定义生物分子能量学方面已经取得了令人兴奋的进展，但要达到对生物分子结构和功能的准确、预测性理解的最终目标，我们还有很多工作要做。

We are requesting funding for a capillary differential scanning calorimeter (DSC); this instrument is a powerful tool for measuring the changes in energy associated with structural transitions and binding interactions for all the major classes of biomolecules, including proteins, nucleic acids, lipids and carbohydrates, as well as smaller ligands, such as metal ions. Thus, DSC is a unique and invaluable tool for analyzing the energetics governing the structure and function of a huge range of biomolecule systems. The understanding of such energetics is essential for manipulating and controlling the behaviour of these systems, in nature, biotechnology and medicine. While there has been exciting progress in defining biomolecule energetics, we still have much work to do to reach the ultimate goal of an accurate, predictive understanding of biomolecule structure and function.