Electromagnetic measurement system for intravascular motion compensation

本研究计划旨在提供经皮冠状动脉介入治疗期间的运动补偿。我们的研究小组最近提出了一种新的基于图像的运动补偿技术，该技术基于单平面x射线血管成像序列。使用模拟结果和离线临床数据集进行验证，但仍需要3D验证。基于2D图像的运动补偿的验证是困难的，因为在干预期间没有可用于比较的3D地面真实运动。一种用于血管内实时导航的电磁测量系统（EMS）将为我们的运动补偿技术提供足够的验证手段。该EMS将提供在一定运动下代表冠状动脉的细长结构的实时6自由度空间测量。一个定制安装的磁性跟踪引导线，通过冠状动脉内的导管插入，将提供实时测量。实时测量将为验证x射线血管造影预测的运动提供最佳方法。EMS测量系统将提供一个基础事实，我们提出的基于图像的运动补偿可以与之进行比较。这将有助于我们的研究生发展严格的方法来验证数据和科学客观性，这是医学影像学研究所必需的。此外，该研究仪器将用于其他血管内研究项目，如需要实时3D位置验证的OCT和IVUS成像。先进的医学图像数据可视化工具对于确保PCI期间的安全导航至关重要。然而，PCI仍然具有很高的挑战性，因为心脏病专家必须依靠偶尔的造影剂注射来评估冠状动脉二维拓扑。术前三维图像与二维在线x线成像图像配准有助于导航指导。本资助申请旨在支持2010年至2014年NSERC个人发现基金。

This research grant proposal aimed at providing motion compensation during percutaneous coronary interventions. A novel image-based motion compensation technique was recently proposed from our research group, based on a monoplane X-ray angiography sequence. A validation was conducted using simulated results and offline clinical datasets, but a validation in 3D is still required. Validation of 2D image-based motion compensation is difficult, since no ground truth motion in 3D is available during the intervention to compare against. An electromagnetic measurement system (EMS) for real-time intravascular navigation would provide an adequate means to validate of our motion compensation technique. This EMS would provide real-time 6 degrees of freedom spatial measurements of elongated structures representing coronary arteries under a certain motion. A custom mounted magnetic tracked guide wire, inserted through a catheter inside a coronary phantom, will provide real-time measurements. Realtime measurements would provide an optimal means of validating the predicted motion from X-ray angiography. The EMS measurement system would provide a ground truth from which our proposed image-based motion compensation can be compared against. This will be helpful for our graduate students to develop a rigorous approach for data validation and scientific objectivity both necessary in medical imaging research. Moreover, this research instrumentation will be used for other intravascular research projects such as OCT and IVUS imaging requiring real time 3D positions for validation purpose. Advanced visualization tools of medical image data are paramount to ensure safe navigation during PCI. However, PCI remains highly challenging since cardiologists must rely on occasional contrast injection to assess coronary topology in 2D. Image registration of preoperative 3D image with 2D online X-ray imaging would be helpful for navigation guidance. This grant application is aimed at supporting an individual NSERC Discovery Grant 2010 to 2014.