Development of prototype test strips for home-use BNP detection

本提案旨在开发一种原型测试条，该测试条集成了基于碳纳米管的全电免疫传感器和微流体通道。目的是验证使用试纸的可行性，通过简单的电子操作，快速检测一滴血中的脑利钠肽（BNP）水平。BNP是一种非常有用的血液分子标志物，可用于心衰的诊断和预后。这项技术最终可能导致家庭使用BNP监测系统，类似于常用的血糖仪。目前还没有家庭使用的BNP测试。这个项目是唐在滑铁卢大学的BIONANO小组和梅斯皮尔生命科学公司的第一个联合研发项目，梅斯皮尔生命科学公司是一家开创性的监测技术公司，对心血管疾病的早期诊断和治疗至关重要。唐氏集团将为拟议的试纸条的建设提供关键的使能技术，而Mespere将提供医疗器械工程方面的专业知识，并协助FDA批准的参考文献的验证。

This proposal is for the development of a prototype test strip, which integrates fully electrical carbon nanotube based immunosensors and microfluidic channels. The goal is to validate the feasibility of using the test strip, operated by simple electronics, to rapidly detect brain natriuretic peptide (BNP) levels in a drop of blood. BNP is a very useful molecular marker in blood for the diagnosis and prognosis of heart failure. The resulted technology could ultimately lead to home-use BNP monitoring systems, similar to the commonly used blood glucose meters. There is no home-use BNP test available currently. This project is the first joint R & D effort by Tang's BIONANO group at University of Waterloo and Mespere Lifesciences, a company pioneering monitoring technologies critical to early diagnosis and treatment of cardiovascular diseases. The Tang group will contribute key enabling technologies for the construction of the proposed test strip and Mespere will contribute expertise in medical device engineering and assist in the validation against FDA approved references.