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Investigation of the roles of GSK-3 isoforms in mediating Abeta, tau and insulin related Alzheimer-like synaptic, cholinergic impairments

Investigation of the roles of GSK-3 isoforms in mediating Abeta, tau and insulin related Alzheimer-like synaptic, cholinergic impairments
研究 GSK-3 亚型在介导 Abeta、tau 和胰岛素相关的阿尔茨海默样突触、胆碱能损伤中的作用
批准号:
264464
负责人:
Woodgett James (Jim) R
金额:
$72.85万
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2012
资助国家:
加拿大
项目状态:
已结题
起止时间:
2012-06-01 至 2016-06-01

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中文摘要
翻译
阿尔茨海默病影响着全球2600多万人,由于人口老龄化,预计到2050年受影响的人数将至少是目前的四倍。目前治疗阿尔茨海默病的方法有助于减缓一些患者的病情进展
英文摘要
Alzheimer's Disease affects over 26 million worldwide and is projected to affect at least four times as many by 2050, as a consequence of our aging populations. The current therapies for Alzheimer's Disease help slow progression in some patients but the d
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会议论文
Genetic analysis of signal transduction pathways involved in human diseases.
Wnt signaling: biomarker and target evaluation in Alzheimer's disease
2012 Synapse Mentorship Award (Research Group) The Samuel lunenfeld Research Institute (SLRI)
  • 批准号:
    257092
  • 项目类别:
  • 资助金额:
    $0.73万
  • 财政年份:
    2012
  • 负责人:
    Woodgett James (Jim) R
  • 依托单位:
Functional roles of glycogen synthase kinase-3 in cellular regulation and cancer
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