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Effect of NPM mutation and NPM-MLF1 translocation on gene regulation

Effect of NPM mutation and NPM-MLF1 translocation on gene regulation
NPM突变和NPM-MLF1易位对基因调控的影响
批准号:
265512
负责人:
Milot Eric
金额:
$47.09万
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2012
资助国家:
加拿大
项目状态:
已结题
起止时间:
2012-09-01 至 2017-09-01

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中文摘要
翻译
NPM基因是包括急性髓系白血病在内的血液系统恶性肿瘤中最常见的突变基因之一。它与多种细胞过程有关,因此,目前尚不清楚NPM突变如何有利于白血病。由于NPM可以
英文摘要
The NPM gene is one of the most frequently mutated gene in hematological malignancies including acute myeloid leukemia. It is implicated in multiple cellular processes and thus, it remains unclear how the NPM mutation can favour leukemia. Since NPM can re
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