Redox stress and neuronal functions

多不饱和脂肪酸（PUFA）的非酶促氧化产生了广泛的氧化产物或氧化脂质体，包括许多醛、异前列烷、异缩酮、神经前列烷和4-HNE。这些产品已被广泛检测到在不同的生物体液和组织样本，以证明脂质过氧化和氧化应激。其中，许多成员是亲电的和反应性的，能够修饰蛋白质上的亲核位点以形成稳定的共价加合物。因此，它们被称为反应性脂质物质（RLS）。我们的工作和其他人的工作表明，RLS可以修饰蛋白质的一个子集，称为亲电响应蛋白质组，它协调生物反应，如与信号转导，线粒体呼吸和细胞死亡或生存途径相关的蛋白质。

The non-enzymatic oxidation of polyunsaturated fatty acids (PUFAs) produced a broad range of oxidation products or oxylipidome including many aldehydes, isoprostanes, isoketals, neuroprostanes, and 4-HNE. These products have been widely detected in different biological fluids and tissue samples to evidence lipoperoxidation and oxidative stress. Among them, many members are electrophilic and reactive, capable of modifying nucleophilic sites on proteins to form stable covalent adducts. They are, therefore, called the reactive lipid species (RLS). Our work and others showed that RLS can modify a subset of proteins, called the electrophile-reponsive proteome, which, in concert orchestrate biological response such as proteins associated with signal transduction, mitochondrial respiration and cell death or survival pathways.