Natural product inspired synthetic methods

拟议的研究计划涉及三个主要调查领域。其中之一是钴催化的5-羟基戊烯有氧氧化合成THF，以及这些氧化反应在全合成中的应用，扩大了反应范围，改善了催化剂性能。 本实验室在这一领域的最新研究成果包括天然产物bullatacin和aerossiallene的不对称全合成。该提案中描述的一个主要合成靶点是amphidinoprotein C。 研究的第二个领域涉及发现给体-受体环丙烷的新反应及其在全合成中的应用。 本工作为吡咯、吲哚、中氮茚及其它有用杂环化合物的合成提供了新的途径，也是近期高诺米汀全合成的关键反应。正在进行的研究将寻找额外的annealing伙伴和环丙烷基序，以及全合成的目标。研究的第三个主要领域涉及基于silole的材料的合作工作。 我们的小组进行的合成和进一步的研究，特别是电致发光和光伏响应，测量丁和Semenikhin组。

The proposed research program involves three primary areas of investigation. One of these features the cobalt catalyzed aerobic oxidations of 5-hydroxy pentenes for THF synthesis, the application of these oxidations in total synthesis, expanding reaction scope and improving catalyst performance. Recent highlights in this area from our lab include the asymmetric total syntheses of the natural products bullatacin and aplysiallene. A major synthetic target described in the proposal is amphidinolide C. A second area of investigation involves the discovery of new reactions of donor-acceptor cyclopropanes and their application in total synthesis. This work has provided new syntheses of pyrroles, indoles, indolizines and other useful heterocycles, and was a key reaction in a recent total synthesis of goniomitine. Ongoing investigations will look for additional annelation partners and cyclopropane motifs, as well as targets for total synthesis. A third major area of research involves collaborative work on silole based materials. Our group performs the syntheses and further studies, particularly electrogenerated chemiluminesence and photo voltaic responses, are measured in the Ding and Semenikhin groups.