Computational methods in modelling fibre-reinforced soft biological tissues

我的研究重点是软生物组织的机械特性，以及它们对外部刺激，生长，适应，失败，退化的反应的调查。我对软组织理论模型的发展特别感兴趣，以便根据组织微观结构预测其机械和物理特性。理论方法是基于用一组方程来描述某一系统。在一些情况下，这些方程可以解析地用来发现物理量之间重要的基本关系。然而，在某些情况下，方程非常复杂，不可能直接推导出任何结果。此外，理论模型不能直接用于解决以复杂几何和/或边界条件为特征的具体问题（例如，具有骨骼、关节软骨、韧带等的生物关节的力学）。

My research focuses on the mechanical properties of soft biological tissues, and the investigation of their response to external stimuli, growth, adaptation, failure, degeneration. I am particularly interested in the development of theoretical models of soft tissues, in order to predict their mechanical and physical properties, based on tissue microstructure. The theoretical approach is based on descriptions of a certain system by means of a set of equations. In several cases, these equations can be used analytically to find important basic relationships between physical quantities. However, there are cases in which the equations are so complex that it is impossible to derive any result directly. Furthermore, theoretical models cannot be directly used to solve specific problems characterised by complex geometry and/or boundary conditions (for example, the mechanics of a biological joint, with bones, articular cartilage, ligaments, etc).