Defining tissue-specific regulation of peroxisome formation/function in Drosophila melanogaster

过氧化物酶体是细胞内调节重要过程的结构，特别是脂质代谢和活性氧解毒。从对酵母等分离细胞的研究中，我们知道有12-32个“基本”基因是形成过氧化物酶体所必需的。然而，我们也已经证明，过氧化物酶体的缺失对形成果蝇各种组织的不同类型有不同的影响。在实验室里，果蝇通常被用来研究形成一个完整动物所需的基本细胞过程。在100多年的科学历史中，果蝇一直被用来确定基因如何调节形成复杂器官的不同类型细胞的发育。

Peroxisomes are structures within cells that regulate important processes, notably lipid metabolism and the detoxification of reactive oxygen. From studies of isolated cells like yeast, we know that there are 12-32 "basic" genes necessary for peroxisome formation. However, we have also shown that loss of peroxisomes causes different effects in the different types that form the various tissues of Drosophila melanogaster (fruit flies). Fruit flies are commonly used in the laboratory to study basic cellular processes that are required to form an entire animal. There is over one hundred years of scientific history where Drosophila has been used to establish how genes regulate development of the different types of cells that form complex organs.