A gold-nanoparticle kit for the development of tailor-made radiodiagnostics and radio-therapeutics

这一建议涉及到各种疾病的成像和治疗的新平台的发展。基本上，由金制成的非常小的颗粒（金纳米颗粒）将装载不同的分子。其中一些分子将把粒子运送到肿瘤或大脑（取决于所选择的分子和所需的应用）。一些其他分子将允许在金粒子上放置放射性标签。这种放射性标签既可以用来定位粒子（从而帮助用成像模式正电子发射断层扫描诊断疾病），也可以用来将放射性传递到身体的某个区域（从而治疗疾病，类似于放射治疗）。

This proposal deals with the development of a new platform for imaging and therapy of various diseases. Basically, very small particles made of gold (gold nanoparticles) will be loaded with different molecules. Some of those molecules will transport the particle to a tumor, or to the brain (depending on the molecule chosen and on the application needed). Some other molecules will allow to put a radioactive tag onto the gold-particle. This radioactive tag can either be used to localize the particle (thus helping to diagnose a disease with the imaging modality positron emission tomography) or to deliver radioactivity to an area of the body (thus treating a disease, similar to radiation therapy).