Unlocking bacterial shapeshifting and its role in antimicrobial resistance

该项目旨在将联合收割机先进的成像技术与创新的微流体技术相结合，以确定如何将微生物变形作为新抗菌剂的目标。由于抗生素耐药性增加而难以治疗的感染不仅对包括牲畜和人类在内的哺乳动物健康产生巨大的全球影响，而且还带来越来越大的经济负担。对微生物生命的深入了解可以推动这一领域迫切需要的进展。具体而言，该项目的成果预计将有助于下一代抗生素的开发。新的基础知识还应有利于转化预防，识别和管理日益严重的国家和全球健康威胁的努力。

This project aims to combine advanced imaging with innovative microfluidics to identify how microbial shapeshifting can be exploited as a target for new antimicrobials. Infections that are hard to treat due to increasing antimicrobial resistance not only have an enormous, global impact on mammalian health, including livestock and humans, but also carry a growing economic burden. Advanced understanding of microbial life can propel urgently needed progress this area. Specifically, the project outcomes are expected to aid the development of next generation antibiotics. The new fundamental knowledge should also benefit translational prevention, identification and management efforts of a rising national and global health threat.