Creation of a super-resolution map of the bacterial cytokinesis machinery

创建细菌胞质分裂机制的超分辨率图

• 批准号: DP220101143
• 负责人: Dr Bill Söderström
• 金额: $ 32.31万
• 依托单位: University of Technology Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-06-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP220101143
• 关键词: Creation; super; resolution; map; bacterial

Cell division is a fundamental process essential for life. Yet our understanding of this process on a molecular level is limited, mostly hampered by the inability to visualize the different components of the division machinery inside these tiny cells with adequate resolution. To overcome this barrier, capitalizing on recent advancements in imaging and molecular technologies combined with innovative engineering, this project aims to create a spatial and temporal map of the division machinery inside bacterial cells at unprecedented resolution. The expected outcomes are new knowledge on the mechanism of bacterial division and technological advances in biological imaging, informing applications in a wide variety of sectors.

细胞分裂是生命的基本过程。然而，我们在分子水平上对这一过程的理解是有限的，主要是由于无法以足够的分辨率可视化这些微小细胞内分裂机制的不同组成部分。为了克服这一障碍，利用成像和分子技术的最新进展与创新工程相结合，该项目旨在以前所未有的分辨率创建细菌细胞内分裂机制的时空图。预期成果是关于细菌分裂机制的新知识和生物成像技术的进步，为各种部门的应用提供信息。