Targeting colorectal cancer-initiating cells and anti-EGFR therapeutic resistance by manipulating levels of the reactive aldehyde, 4-hydroxynonenal
Targeting colorectal cancer-initiating cells and anti-EGFR therapeutic resistance by manipulating levels of the reactive aldehyde, 4-hydroxynonenal
批准号:
281581
负责人:
O'Brien Catherine A
金额:
$45.58万
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2013
资助国家:
加拿大
项目状态:
已结题
起止时间:
2013-03-01 至 2017-03-01
中文摘要
结直肠癌(CRC)是加拿大癌症死亡的第二大原因,每年有9,200人死亡。我们先前已经表明,CRC是由结肠直肠癌起始细胞(CC-IC)的子集启动和维持的。此外,
英文摘要
Colorectal cancer (CRC) is the 2nd leading cause of cancer mortality in Canada, with 9,200 deaths annually. We have previously shown that CRCs are initiated and maintained by a subset of colorectal cancer-initiating cells (CC-ICs). There is also increasin
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会议论文
Inhibition of CBP/p300 bromodomain activity increases chemosensitivity of p53 mutant colorectal cancers through inhibiting p53 aggregation
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批准号:472399
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资助金额:$7.29万
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依托单位:
Canada Research Chair - Tier 2
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批准号:415401
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项目类别:
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资助金额:$43.71万
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Colorectal cancer stem cell plasticity: A novel therapeutic target
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批准号:334266
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资助金额:$88.93万
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财政年份:2015
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依托单位:
Targeting colorectal cancer-initiating cells and anti-EGFR therapeutic resistance by manipulating levels of the reactive aldehyde, 4-hydroxynonenal.
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批准号:302201
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项目类别:Salary Programs
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资助金额:$21.86万
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财政年份:2013
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负责人:O'Brien Catherine A
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依托单位:
海外基金