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Coordinating DNA deamination, double strand break and repair to prevent genomic instability during antibody gene diversification.

Coordinating DNA deamination, double strand break and repair to prevent genomic instability during antibody gene diversification.
协调 DNA 脱氨基、双链断裂和修复,以防止抗体基因多样化过程中基因组不稳定。
批准号:
280743
负责人:
Di Noia Javier M
金额:
$38.5万
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2013
资助国家:
加拿大
项目状态:
已结题
起止时间:
2013-03-01 至 2017-03-01

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中文摘要
翻译
抗体可以识别和消除任何病原体或毒素。由于病原体几乎是无限的,抗体需要适应。为了做到这一点,几乎每个B淋巴细胞都会在两个区域修改编码抗体的基因。一个是结合的区域
英文摘要
Antibodies can recognize and eliminate any pathogen or toxin. Since pathogens are virtually infinite, antibodies need to adapt. To do this, almost every B lymphocyte modifies the genes that encode its antibody in two regions. One is the region that binds
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会议论文
Molecular mechanisms underlying high-affinity and isotype switched antibody responses
Regulation of germinal center B cell function during antibody responses
DNA deamination in adaptive and innate immunity: 20 years after the discovery of Activation induced deaminase
Regulation and impact of productive AID targeting during antibody responses.
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