Biosurface modification using nanoparticles to manage infected dentin

龋齿是由细菌引起的最常见的口腔疾病。尽管在修复治疗方面有所改善，但复发性龋齿的患病率仍在上升。在发达国家，预防龋齿进展的努力也已成为减少龋齿患病率的首要重点。近年来，龋齿的治疗已以微创治疗为基础。对于这种微创治疗方案，已经提出了一些具体的目标：抑制活跃的龋齿病变，使充填-牙本质界面再矿化，稳定受感染的牙本质，尽量减少修复体放置时的组织移除。在本项目中，我们提出了开发抗菌纳米颗粒的可能性，该纳米颗粒具有改善充填-牙本质界面和阻断牙本质小管的能力，以实现龋齿微创治疗的关键治疗要求。这种基于纳米颗粒的方法有可能提高龋齿微创治疗的治疗效果。目前的研究将启动一个生产和供应修复材料/牙齿清漆的行业（Germiphene公司）与多伦多大学的研究人员之间的互动和发展密切的合作，多伦多大学的研究人员拥有多功能纳米颗粒的专业知识。

Dental caries is the most common disease of oral cavity caused by bacteria. Despite the improvements in the restorative treatment, the prevalence of recurrent caries is on the rise. Attempts to prevent caries progression in the developed world have also been of prime focus in order to reduce the prevalence of caries. Recently the treatment of carious lesions has been based on minimally invasive options. Certain specific goals have been outlined for this minimally invasive treatment options: arrest of the active carious lesions, ability to remineralize the filling-dentin interface, stabilization of the infected dentin and minimal removal of tissue for the placement of restorations. In this project we propose the possibility of developing antibacterial nanoparticles with ability to improve filling-dentin interface and block patent dentinal tubules to achieve the key therapeutic requirements in the minimally invasive management of dental caries. This nanoparticles based approach has the potential to enhance treatment outcomes in the minimally invasive management of dental caries. The current research will initiate interaction and develop close collaboration between an industry (Germiphene Corporation) that produces and supplies restorative material/tooth varnish with the University of Toronto researchers who have the expertise in multifunctional nanoparticles.