Towards the sustainable discovery and development of new antibiotics

该项目旨在确定如何获取微生物基因组中沉默的生物合成基因，以促进获取隐藏在微生物基因组中的新化学多样性。利用基因组挖掘和代谢组学技术的跨学科方法，该项目有望激发和实现未来更有效抗生素的设计。该计划的预期成果包括定义新的微生物防御分子，以满足农业化学和环境科学的未来需求。它还将培养未来的科学家并发展国际合作。这将带来巨大的好处，包括更高质量的研究和创新劳动力，使澳大利亚处于药物发现的最前沿。

This project aims to define how to access silent biosynthetic genes within microbial genome to facilitate access to new chemical diversity hidden within microbial genomes. Using interdisciplinary approaches in genome mining and metabolomics technologies, the project expects to inspire and enable the future design of more effective antibiotics. Expected outcomes from this program include define new microbial defence molecules, to meet future demands in agrochemical and environmental sciences. It will also train future scientists and develop international collaborations. This should provide significant benefit, including a higher-quality workforce for research and innovation, positioning Australia at the forefront of drug discovery.