New Developments in Organic Chemistry: Methods and Total Synthesis

提出的研究计划旨在开发新的策略和新的合成方法和试剂，以有效地形成碳-碳和碳杂原子键。能够以选择性方式生成产物的方法，无论是位点选择性、化学选择性还是立体选择性的方式，都是特别重要的，因为它们可以用于复杂分子的受控和可预测的合成。过渡金属催化的使用为实现这一目标提供了一种方法，而多米诺反应序列的发展将允许快速构建分子复杂性。当前提案中概述的具体项目包括周环反应，有机硼和炔化学的发展。将确定这些方法的范围，并在适当情况下确定反应的机制。这些合成方法将直接应用于生物相关和结构复杂的靶分子的合成，包括具有抗癌或抗生素活性的天然产物，如大环沉积肽和生物碱。

The proposed research program is aimed at the development of novel strategies and new synthetic methods and reagents for the efficient formation of carbon-carbon and carbon-heteroatom bonds. Methods that can generate products in a selective manner, whether in a site selective, chemoselective or stereoselective fashion are of particular importance, since they can then be used for the controlled and predictable synthesis of complex molecules. The use of transition metal catalysis provides one approach to achieve this goal, while the development of domino reaction sequences will allow for the rapid construction of molecular complexity. Specific projects outlined in the current proposal include the development of pericyclic reactions, organoboron and alkyne chemistry. The scope of these methods and, where appropriate, the mechanism of the reactions will be determined. The synthetic methods will be applied directly to the syntheses of biologically relevant and structurally complex taregt molecules, including natural products which display anticancer or antibiotic activity, such as macrocylic depsipeptides and alkaloids.